Parry–Romberg syndrome is a rare disorder characterized by slowly progressive degeneration (atrophy) of the soft tissues of half of the face. Generally the first sign is facial changes above the upper jaw or between the nose and upper corner of the lip. As the soft tissue and fat begin to shrink, the skin starts to sink in and distort the face. Over the next three to five years, the mouth, eyebrow, ear, and cheek on the affected side begin to change as well.

There is no cure for Parry-Romberg syndrome. Nor are there any proven treatments, although drugs that suppress the immune system have been shown to be beneficial in some cases. Recently, doctors saved a little girls face from Parry-Romberg syndrome.